In Italy, Serie A winners Napoli were handed a shock defeat at Monza.
Barcelona secured their first LaLiga title since 2019 after beating city rivals Espanyol 4-2.
However, the celebrations were cut short when Espanyol fans ran onto the pitch after the match as the Barcelona players soaked up the win. Players were forced to sprint into the tunnel.
Robert Lewandowski scored either side of Alejandro Balde’s 20th-minute goal before Jules Kounde added his fourth just after half-time.
Javier Puado pulled one back for Espanyol and Joselu added another in stoppage time, but victory means Barcelona will be 14 points clear of Real Madrid at the summit with just four games remaining.
Atlético Madrid missed the chance to overtake second-placed Real Madrid after going down 1-0 to bottom-of-the-table Elche when a mistake from goalkeeper Ivo Grbic allowed Fidel to tap in just before the break.
Three second-half goals were enough for Sevilla to seal a comfortable victory against relegated Real Valladolid.
Rafa Mir put the visitors ahead and Papu Gomez doubled their lead before Tecatito Corona, in his first game since August, wrapped up the game with a stoppage time goal.
Alberto Mari scored a late goal for Valencia to win 2-1 against Celta Vigo.
Justin Kluivert put the visitors ahead before Haris Seferovic equalised, but Mari found the winner before Valencia’s Gabriel Paulista received a second yellow card.
Marseille remain third in Ligue 1 after coming from behind to beat bottom side Angers 3-1.
The visitors went ahead through Abdallah Sima, but Alexis Sanchez quickly equalized before Dimitri Payet and Jordan Veretout sealed the three points.
Rennes continued their push for European football with a 4-0 win over Troyes after Arthur Theate and Benjamin Bourigeaud put them in control and Karl Toko Ekambi scored twice in four minutes.
Two goals from Grejohn Kyei canceled out Alexandre Lacazette’s strike as Clermont beat Lyon 2-1 and Jeremy Le Douaron’s second-half goal was enough for Brest to beat Auxerre 1-0.
Faitout Maouassa rescued Montpellier a point in stoppage time as they drew 1-1 with Lorient, while Toulouse’s clash with Nantes and Lille’s visit to Monaco ended goalless.
Leipzig climbed back up to third in the Bundesliga table after late goals from Willi Orban and Dominik Szoboszlai secured a 2-1 win against Werder Bremen, who advanced through Leonard Bittencourt.
Bayer Leverkusen had to settle for a 1-1 draw at Stuttgart after Exequiel Palacios’ penalty canceled out Serjo Guirassy’s earlier free-kick.
Serie A champions Napoli were surprised to be beaten 2-0 by Monza thanks to goals from Dani Mota and Andrea Petagna.
Juventus remain second in the table after Nicolo Fagioli’s stunning first strike and a goal from Bremer earned them a 2-0 win against Cremonese, but Europa League semi-finalists Roma had to share the spoils after drawing 0-0 with Bologna.
Nikola Vlasic’s first-half strike was enough to see Turin beat Hellas Verona 1-0 and Fiorentina secure a 2-0 win against Udinese.
Gaetano Castrovilli scored in the early stages before Giacomo Bonaventura added his second goal. But the match ended on a sour note when Bonaventura and Udinese’s Rodrigo Becao were sent off for violent conduct.
