The Brazilian was sent off for the second time this season during last week’s draw with Southampton and will miss several key games for Erik ten Haga’s side.
Anthony Martial is not expected to feature in Sunday afternoon’s game despite the Frenchman recently returning to training.
Winger Antony missed the win over Real Betis and could sit out again.
However, Marcel Sabitzer is likely to start at Old Trafford as attention turns to trying to reach Wembley for a second time this season.
Alejandro Garnacho, Christian Eriksen and Donny van de Beek are long-term absentees for United.
Predicted Manchester United XI:
De Gea; Wan-Bissaka, Varane, Martinez, Shaw; Sabitzer, Fred; Sancho, Fernandes, Rashford; Weghorst.