The Tottenham striker has been training in a protective mask after fracturing his eye socket in early November.
The player is keen to play and suggested before the tournament that he would be willing to risk further injury to lead his nation.
Coach Paulo Bento said before the match: “We hope he will be as comfortable as possible and we will use the best strategies to make him feel at ease.
“But he knows, and we know, that we can’t rule out any risk after this injury.
Left-back Kim Jin-su has been struggling with a hamstring injury for the past month or so and is also a doubt for Bent’s side.
A lack of confidence in his other wide defensive options could therefore prompt Korea to consider switching to a back three.
Two-time World Cup winners Uruguay have heaps of experience in their 26-man squad for the tournament in Qatar.
Ronald Araujo is their big injury concern – the Barcelona defender has not featured at club level for several months and reports suggest he could miss at least Uruguay’s first two matches.
Diego Godin and Jose Gimenez could link up again in central defense, while Rodrigo Bentancur, Matías Vecino and Fede Valverde form part of one of the more balanced central midfields at the tournament.
The forward line may feature two men who have called Liverpool home in Luis Suarez and Darwin Nunez.
Predicted Uruguay XI (4-3-1-2):
Rochet; Varela, Godin, Gimenez, Olivera; Bentancur, Torreira, Vecino; Valverde; Suarez, Nunez.
Predicted South Korea XI (4-3-3):
Kim Seung-gyu; Yoon Jong-gyu, Kim Min-jae, Kim Young-gwon, Kim Jin-su; Jung Woo-young, Hwang In-beom, Kwon Chang-hoon; Hwang Hee-chan, Hwang Ui-jo, Heung-min Son.