Manchester City will hope to welcome back Rodri for the visit of Southampton.
The Premier League champions were without their influential midfielder in the Manchester derby but he didn’t seem to miss him in a 6-3 win in which the scoreline flattered Manchester United.
Ilkay Gundogan would likely drop back, with Kevin De Bruyne and Bernardo Silva forming a midfield three.
Kyle Walker is predictably out with groin surgery and his World Cup place is now also under threat, so Joao Cancelo will continue at right-back as Sergio Gomez gets another chance at left-back. Ruben Dias missed the derby starting eleven, so he should start this weekend.
Up front, it will likely be the same case with derby hat-trick heroes Erling Haaland and Phil Foden alongside Jack Grealish, who has been really successful this season.
Manchester City predicted XI: Ederson; Cancelo, Dias, Ake, Gomez; De Bruyne, Rodri, Bernardo; Foden, Haaland, Grealish
Southampton predicted XI: Bazunu; Walker-Peters, Bella-Kotchap, Caleta-Car, Larios; Armstrong, Ward-Prowse, Diallo, Aribo; Mara, Adams