Bayern have already progressed to the knockout stage, boasting a perfect record of four wins from four, but would still welcome the scalp of another European giant who have already beaten Inter.
Inter face a group of whipping boys Viktoria Plzeň in the earlier kick-off and are expected to beat the Czech side, which would leave them in the next round and Barcelona out of the competition.
However, if Pilsen gets some points and Barcelona beats Bayern, there is a chance they will stay in the competition.
Barcelona vs Bayern Munich predicted line-ups
Ronald Araujo will miss the game after undergoing groin surgery in September, while Sergi Robertodislocated his shoulder at the weekend and will also miss out.
Andreas Christensen and Memphis Depay are both doubtful, while Gavi took a hit to his abductor muscle at the weekend but is expected to play.
Bayern Munich, meanwhile, are without Manuel Neuer, Lucas Hernandez, Leroy Sane and Bouna Sarr.
Barcelona’s predicted lineup (4-3-3): Ter Stegen; Bellerin, Kounde, E Garcia, Alonso; De Jong, Busquets, Pedri; Dembele, Lewandowski, Gavi.
Bayern Munich’s predicted lineup (4-2-3-1): Ulreich; Pavard, Upamecano, De Ligt, Davies; Kimmich, Goretzka; Coman, Musiala, Gnabry; Mane.